Brief Communication | Open Access
James R. Gray, Urs P. Steinbrecher, "False Positive Anti-Hepatitis A Virus IgM Result in a Patient with Autoimmune Hepatitis", Canadian Journal of Gastroenterology and Hepatology, vol. 3, Article ID 389354, 4 pages, 1989. https://doi.org/10.1155/1989/389354
False Positive Anti-Hepatitis A Virus IgM Result in a Patient with Autoimmune Hepatitis
This report describes a patient with autoimmune hepatitis in whom a positive test result for hepatitis A virus (HAV) IgM antibody led to diagnostic confusion until it was shown to be false positive by immunoprecipitation of IgG from serum. The mechanism for the false positive result may have been related to marked hypergammaglobulinemia, as serum obtained after normalization of immunoglobulin levels tested negative. However, several other mechanisms were also considered. This case illustrates that the possibility of false positive results with the anti-HAV lgM assay should be kept in mind when the clinical features of the illness are not suggestive of acute hepatitis A.
Copyright © 1989 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.