Abstract
A 43-year-old man with longstanding ulcerative colitis developed primary sclerosing cholangitis established by cholangiography and liver biopsy. Within one year of the diagnosis of primary sclerosing cholangitis, pulmonary sarcoidosis developed, proven by chest x-ray and transbronchial biopsy. The sarcoidosis initially presented with systemic systems rather than dyspnea. The relationship between primary sclerosing cholangitis, sarcoidosis and the symptomatology are discussed. Concomitant primary sclerosing cholangitis and sarcoidosis may be more common than previously anticipated and could be a further manifestation of disordered immune regulation.