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Canadian Journal of Gastroenterology
Volume 4, Issue 1, Pages 19-22
Brief Communication

Collagenous Colitis: Histologic Progression, Extraintestinal Features and Lack of Response to 5-ASA - A Case Report

Franzjosef Schweiger

The Moncton Hospital, Moncton, New Brunswick, Canada

Received 23 June 1988; Accepted 13 November 1989

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Collagenous colitis is a clinicopathologic syndrome which presents as chronic, watery, nonbloody diarrhea. Colonic biopsies characteristically show a thick subepithelial collagen band. Barium enema and colonoscopy generally fail to establish the diagnosis. This case report provides evidence for histologic progression over time, pancolonic involvement and the presence of extraintestinal features of collagenous colitis. The reported patient showed no response to 5-aminosalicylic acid. Colonoscopic biopsies in cases of chronic diarrhea can save the patient repeated, uncomfortable and costly investigations.