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Canadian Journal of Gastroenterology
Volume 4, Issue 7, Pages 384-389
IDB: Carcinogenesis

Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease

J Chen,1,3 C-M Chai,1 W Dalu,1 L Shen,1 F Fromowitz,1,3 C Compton,1,3 and MV Viola1,3

1Departments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USA
2Departments of Surgery and Pathology, Suzhou Medical College, Suzhou, China
3Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that the frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid substitutions, were similar in sporadic colon cancers, cancers associated with ulcerative colitis in the United States, and colon cancers found in patients with schistosomal colitis in Jiangsu province in China. Further, activating mutations of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic ulcerative colitis. The latter finding indicates that some dysplasias are clonal proliferative lesions with genetic characteristics associated with invasive cancer.