Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1990 / Article

Clinical Gastroenterology | Open Access

Volume 4 |Article ID 437472 | https://doi.org/10.1155/1990/437472

Pierre Paré, Robert J Bailey, André P Archambault, Henri Navert, C Noel Williams, ABR Thomson, Denis Levesque, Alain Farley, "Healing of Benign Gastric and Prepyloric Ulcers: A Prospective, Endoscopy-Controlled, Randomized, Double-Blind, Canadian Multicentre Study of Omeprazole 20 and 40 mg Daily and Rantidine 150 mg Twice a Day", Canadian Journal of Gastroenterology and Hepatology, vol. 4, Article ID 437472, 6 pages, 1990. https://doi.org/10.1155/1990/437472

Healing of Benign Gastric and Prepyloric Ulcers: A Prospective, Endoscopy-Controlled, Randomized, Double-Blind, Canadian Multicentre Study of Omeprazole 20 and 40 mg Daily and Rantidine 150 mg Twice a Day

Received21 Jun 1989
Accepted13 Nov 1989

Abstract

A double-blind, randomized study was conducted in 118 patients with benign gastric or prepyloric ulcers to compare the efficacy of omeprazole 20 or 40 mg daily with ranitidine 150 mg twice daily. The healing rates at four weeks were 67, 79 and 54% and at eight weeks increased to 90, 97 and 71 % for the omeprazole 20 and 40 mg groups and the ranitidine group, respectively (P< 0.03 for the differences between each of the omeprazole groups and the ranitidine group at eight weeks). Multivariate analysis showed influence on healing rate for ulcer size but not for smoking status, sex or ulcer site. Symptomatic relief was excellent and similar in the three groups. Ulcer recurrence during the six month follow-up off treatment after initial ulcer healing did not differ between the three groups. No serious adverse events could be attributed to the drugs. The authors conclude that treatment with omeprazole 20 or 40 mg daily for a period of four to eight weeks is safe and significantly more effective in ulcer healing than a standard dose of ranitidine.

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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