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Canadian Journal of Gastroenterology
Volume 4 (1990), Issue 1, Pages 7-12
http://dx.doi.org/10.1155/1990/437472
Clinical Gastroenterology

Healing of Benign Gastric and Prepyloric Ulcers: A Prospective, Endoscopy-Controlled, Randomized, Double-Blind, Canadian Multicentre Study of Omeprazole 20 and 40 mg Daily and Rantidine 150 mg Twice a Day

Pierre Paré,1,2,3,4 Robert J Bailey,2,4 André P Archambault,2,3,4 Henri Navert,2,3,4 C Noel Williams,2,5 ABR Thomson,2,5,6 Denis Levesque,1,2,3,4 and Alain Farley2,3,4

1Division of Gastroenterology, Hôtel-Dieu de Québec Hospital, Laval University, Quebec City, Quebec, Canada
2Internal Medicine, Royal Alexandra Hospital, Edmonton, Alberta, Canada
3Centre de Gastro-entérologie et d’ Endoscopie de Montréal and Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
4Centre de Recherche en Physiopathologie Digestive, University of Sherbrooke, Sherbrooke, Quebec, Canada
5Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada
6Division of Gastroenterology, University of Alberta, Edmonton , Alberta, Canada

Received 21 June 1989; Accepted 13 November 1989

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A double-blind, randomized study was conducted in 118 patients with benign gastric or prepyloric ulcers to compare the efficacy of omeprazole 20 or 40 mg daily with ranitidine 150 mg twice daily. The healing rates at four weeks were 67, 79 and 54% and at eight weeks increased to 90, 97 and 71 % for the omeprazole 20 and 40 mg groups and the ranitidine group, respectively (P< 0.03 for the differences between each of the omeprazole groups and the ranitidine group at eight weeks). Multivariate analysis showed influence on healing rate for ulcer size but not for smoking status, sex or ulcer site. Symptomatic relief was excellent and similar in the three groups. Ulcer recurrence during the six month follow-up off treatment after initial ulcer healing did not differ between the three groups. No serious adverse events could be attributed to the drugs. The authors conclude that treatment with omeprazole 20 or 40 mg daily for a period of four to eight weeks is safe and significantly more effective in ulcer healing than a standard dose of ranitidine.