Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1991 / Article

Review | Open Access

Volume 5 |Article ID 210541 |

André Buret, "Defence Mechanisms during Intestinal Infection", Canadian Journal of Gastroenterology and Hepatology, vol. 5, Article ID 210541, 9 pages, 1991.

Defence Mechanisms during Intestinal Infection

Received24 Apr 1990
Accepted01 Oct 1990


This review examines and compares host defence mechanisms during intestinal infection with three types of organisms: a virus, a bacterium and a nematode parasite (ie, transmissible gastroenteritis virus [TGEV], Helicobacter jejuni and Trichinella spiralis). Diarrhea is commonly associated with all of these infections. It appears that T spiralis initiates the most elaborate defence system of the three organisms, involving full range humoral and cellular immunity, as well as mucus hypersecretion, epithelial alterations, altered gut motility and parasite impairment (morphological and physiological). In contrast, intestinal defence against H jejuni and TGEV involves fewer components. The latter seems to initiate the most rudimentary host response. Despite such differences, these mechanisms exhibit many similarities, thus further illustrating the relatively limited repertoire of defence systems that the intestine can mount. The mediators translating the insult of any intestinal pathogen into a common response deserve further investigation.

Copyright © 1991 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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