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Canadian Journal of Gastroenterology
Volume 5, Issue 4, Pages 154-160

Small Bowel Transplantation: Current Clinical Status

David Sigalet

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

Received 28 March 1991; Accepted 17 July 1991

Copyright © 1991 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


With recent refinements in immunosuppression techniques, the first successful reports of small bowel transplantation in humans have now been made, increasing interest in bowel transplantation among clinicians and patients alike. This article reviews recent developments in understanding of the functional capabilities and requirements for effective immune suppression in bowel transplantation. Both experimental and clinical experience with transplantation are discussed, as are the areas which appear to offer the most promise for future developments. Finally guidelines for consideration of patient selection for this procedure are reviewed.