Clinical Gastroenterology | Open Access
Mark A Kostash, Richard Johnston, RJ Bailey, Elsie M Konopad, Lorraine P Guthrie, "Sedation for Colonoscopy: A Double-Blind Comparison of Diazepam/Meperidine, Midazolam/Fentanyl and Propofol/Fentanyl Combinations", Canadian Journal of Gastroenterology and Hepatology, vol. 8, Article ID 259528, 5 pages, 1994. https://doi.org/10.1155/1994/259528
Sedation for Colonoscopy: A Double-Blind Comparison of Diazepam/Meperidine, Midazolam/Fentanyl and Propofol/Fentanyl Combinations
Rate of recovery and incidence of complications were compared among three intravenous sedation techniques for colonoscopy. Sixty patients were randomized to receive diazepam and meperidine, midazolam and fentanyl, or propofol and fentanyl with a continuous infusion of propofol. Patients were sedated to a standard end-point using a double-blinded technique. There were no differences in rate of recovery or incidence of minor side effects among the three groups. The techniques were equally effective in providing sedation and analgesia for colonoscopy. All groups developed significant oxygen desaturation measured by continuous pulse oximetry. Over 20% of patients required supplemental oxygen due to persistent desaturation below 85% following administration of sedatives. The authors conclude that oxygen should be administered to all patients undergoing colonoscopy.
Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.