Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1995 / Article

Brief Communication – Hepatology | Open Access

Volume 9 |Article ID 649852 |

Mark R Oliver, Alfredo Pinto, R Brent Scott, "Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology", Canadian Journal of Gastroenterology and Hepatology, vol. 9, Article ID 649852, 4 pages, 1995.

Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology


An infant girl who presented with cholestasis and hepatitis that rapidly progressed to fulminant liver failure is reported. Postmortem examination yielded a diagnosis of demonstrated extensive hepatic necrosis due to adenovirus type 5 infection which had developed in the setting of an occult primary immunodeficiency (severe combined immunodeficiency). The aim of this report is to alert the physician to a rare cause of cholestasis and hepatitis in infancy. Recognition of the combination of adenoviral infection with underlying primary immunodeficiency is a prerequisite to the provision of genetic counselling.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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