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Canadian Journal of Gastroenterology
Volume 10, Issue 7, Pages 440-442
Brief Communication

Colonic Carcinoma in Two Adult Cystic Fibrosis Patients

H Chaun, B Paty, EM Nakielna, N Schmidt, Jk Holden, and B Melosky

Adult Cystic Fibrosis Clinic and Departments of Medicine, Surgery and Pathology, St Paul’s Hospital, and University of British Columbia, Vancouver, British Columbia, Canada

Received 24 November 1995; Revised 2 April 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two adult women with cystic fibrosis (CF) who developed colonic carcinoma, both at age 31, are described. In both patients the carcinoma occurred in the midtransverse colon. The diagnosis had not been suspected, partly because of the patients’ relatively young age. In case 1, the symptoms also mimicked the distal intestinal obstruction syndrome. At diagnosis she was shown to have metastases to the regional lymph nodes. In case 2, despite a long history of chronic pulmonary and sinus disorders, CF was not diagnosed until the patient was 36 years old. The incidence of gastrointestinal malignancies has been shown to be significantly increased in patients with CF. As the life expectancy of the CF population increases, vigilance for gastrointestinal cancers in CF patients is important, as illustrated by these two cases.