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Canadian Journal of Gastroenterology
Volume 10, Issue 3, Pages 191-198

Growth Factors in Inflammatory Bowel Disease

Nicholas Wright

Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, and Histopathology Unit, Imperial Cancer Research Campaign Laboratories, Lincoln’s Inn Fields, London, UK

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Growth factors have many influences on the gastrointestinal tract, not just modulating cell proliferation, but also acting on other aspects of physiology. Several of these functions are incriminated in the pathogenetic and healing phenomena that accompany inflammatory bowel disease (IBD). A review of growth regulation in the intestine is presented. Topics include growth phenomena in IBD, sources of growth factors, growth factors in gut growth responses, trefoil peptides, other growth factors and role of growth factors in IBD.