Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1996 / Article

Brief Communication | Open Access

Volume 10 |Article ID 917908 |

Robert Enns, Guido van Rosendaal, "Hypogammaglobulinemia in a Family with Crohn’s Disease", Canadian Journal of Gastroenterology and Hepatology, vol. 10, Article ID 917908, 3 pages, 1996.

Hypogammaglobulinemia in a Family with Crohn’s Disease


A 55-year-old woman presented with steroid refractory Crohn’s disease. In anticipation of surgical therapy, a protein electrophoresis was done and demonstrated low serum immunoglobulins. Immunoglobulin analysis showed low levels of serum immunoglobulin G, which persisted following surgical therapy despite a clinical remission. A diagnosis of combined variable hypogammaglobulinemia was made and her family was screened for a similar disorder. Four of the six family members known to have Crohn’s disease were discovered to have low serum immunoglobulins. The presented patient was the index case in a family who has both hypogammaglobulinemia and Crohn’s disease. Furthermore, the two disorders in this family appear to be closely linked. Future study of the association between these two disorders may enable a more clear definition of Crohn’s disease pathogenesis.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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