Brief Communication | Open Access
Nir Hilzenrat, Esther Lamoureux, Averell Sherker, Albert Cohen, "Cholestasis in Crohn's Disease: A Diagnostic Challenge", Canadian Journal of Gastroenterology and Hepatology, vol. 11, Article ID 203843, 3 pages, 1997. https://doi.org/10.1155/1997/203843
Cholestasis in Crohn's Disease: A Diagnostic Challenge
A 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. The first episode was related to an idiosyncratic drug reaction while on sulfasalazine. The second episode, at the time of an exacerbation of his colitis, was characterized by moderate portal inflammation on liver biopsy and resolved quickly while he was on corticosteroid therapy. The most recent episode, occurring when the bowel disease was quiescent, was due to granulomatous hepatitis and resolved clinically with no specific therapy. Because numerous potentially serious hepatobiliary complications have been associated with inflammatory bowel disease, prompt and aggressive investigation in these instances is recommended.
Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.