Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 1997 / Article

Original Article | Open Access

Volume 11 |Article ID 627297 | https://doi.org/10.1155/1997/627297

Masafumi Komatsu, Tohru Ishii, Tsuyoshi Ono, Takao Hoshino, Tomoyuki Kuramitsu, Takashi Goto, Tomoo Fujii, Itaru Toyoshima, Mitsuro Chiba, Osamu Masamune, "Pilot Study of Ofloxacin and Interferon-Alpha Combination Therapy for Chronic Hepatitis C without Sustained Response to Initial Interferon Therapy", Canadian Journal of Gastroenterology and Hepatology, vol. 11, Article ID 627297, 5 pages, 1997. https://doi.org/10.1155/1997/627297

Pilot Study of Ofloxacin and Interferon-Alpha Combination Therapy for Chronic Hepatitis C without Sustained Response to Initial Interferon Therapy

Received29 Jan 1997
Accepted28 May 1997

Abstract

A controlled trial comparing combination therapy with ofloxacin (OFLX) and interferon (IFN) versus IFN monotherapy was conducted in patients with chronic hepatitis C who failed IFN therapy. Twenty patients were assigned randomly to two groups. Equal doses of recombinant IFNα-2b were administered to each group for 24 weeks. For the IFN plus OFLX group, OFLX was administered for 12 weeks at a daily dose of 600 mg. Levels of hepatitis C virus RNA declined significantly from the first month after the start of IFN treatment compared with those before administration in both groups. Serum alanine aminotransferase levels were significantly lower in the IFN plus OFLX group at two and six months after the start of treatment than levels in the IFN group. The fraction of subjects whose levels of serum ALT normalized was also higher in the IFN plus OFLX group. Larger clinical trials should be undertaken.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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