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Canadian Journal of Gastroenterology
Volume 12, Issue 4, Pages 273-275
Consultations in Gastroenterology

Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance

John K Marshall and E Jan Irvine

Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients - one each with Crohn's disease, ulcerative colitis and collagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.