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Canadian Journal of Gastroenterology
Volume 13, Issue 3, Pages 265-269
http://dx.doi.org/10.1155/1999/194367
Review

Serological Testing in Screening for Adult Celiac Disease

Helen Rachel Gillett and Hugh James Freeman

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Assays for celiac-related antibodies are becoming widely available, and the present review aims to clarify the use of these investigations in the diagnosis of, management of and screening for adult celiac disease. The sensitivities and specificities of various antibody tests are discussed, along with their clinical use as an adjunct to small bowel biopsy, and as a first-line investigation for patients with atypical symptoms of celiac disease or patients at high risk of developing sprue.