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Canadian Journal of Gastroenterology
Volume 13, Issue 2, Pages 143-145
NSAID Gastroenteropathy

What Do We Do about Helicobacter pylori?

CJ Hawkey

Division of Gastroenterology, University Hospital, Nottingham, UK

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Heliobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) cause ulcers by different mechanisms. Under some circumstances, patients infected with H pylori may be less prone to NSAID-associated ulcers than those who are H pylori-negative. Eradication trials have yielded differing results. However, those who have studied patients who have a past history of ulcer disease and are already established on NSAIDs have shown no benefit from H pylori eradication.