Brief Communication | Open Access
Hugh J Freeman, "Hyposplenism, Antiendomysial Antibodies and Lymphocytic Colitis in Collagenous Sprue", Canadian Journal of Gastroenterology and Hepatology, vol. 13, Article ID 596427, 4 pages, 1999. https://doi.org/10.1155/1999/596427
Hyposplenism, Antiendomysial Antibodies and Lymphocytic Colitis in Collagenous Sprue
A 66-year-old woman was seen repeatedly over a decade to remove recurrent colonic adenomas and investigate episodes of watery diarrhea. Although the diarrhea was believed to be due to lymphocytic colitis, she developed weight loss, hypoproteinemia and hyposplenism that resulted in further studies, specifically to exclude celiac disease. Small intestinal biopsies, however, showed severely ‘flattened’ villous architecture with trichrome-positive subepithelial collagenous deposits, characteristic of collagenous sprue. Antiendomysial antibodies, known serological markers of celiac disease, were also detected. While collagenous sprue has been considered a distinct small intestinal disorder, the constellation of clinical and pathological findings in this patient suggests a close link with adult celiac disease.
Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.