Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 2000 / Article

Original Article | Open Access

Volume 14 |Article ID 219623 | https://doi.org/10.1155/2000/219623

Kamel Gharzouli, Smain Amira, Seddik Khennouf, Akila Gharzouli, "Effects of Sodium Fluoride on Water and Acid Secretion, Soluble Mucus and Adherent Mucus of the Rat Stomach", Canadian Journal of Gastroenterology and Hepatology, vol. 14, Article ID 219623, 6 pages, 2000. https://doi.org/10.1155/2000/219623

Effects of Sodium Fluoride on Water and Acid Secretion, Soluble Mucus and Adherent Mucus of the Rat Stomach

Received30 Jun 1998
Revised23 Feb 1999

Abstract

Chronic and acute ingestion of fluoride may lead to both structural and functional alterations of the gastric mucosa. The aim of this study was to investigate the effects of sodium fluoride on gastric secretion and mucosal barrier. Filling the rat stomach for 1 h with sodium fluoride (5 and 20 mmol/L) induced an increase in fluid, fucose and galactose output. This effect was accompanied by a marked pH-dependent reduction of titratable acidity of the lumen. The amount of Alcian blue bound to adherent mucus was reduced in a pH-independent manner by sodium fluoride. The absence of a correlation between soluble glycoproteins and adherent mucus suggests that sodium fluoride does not stimulate mucus secretion, but rather acts as a barrier-breaking agent by its accumulation, together with acid, into the mucosa.

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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