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Canadian Journal of Gastroenterology
Volume 14, Issue 4, Pages 277-282
Original Research

Effect of Acid-Suppressive Therapy on Helicobactor pylori Production of Interleukin-8 in Gastric Mucosa

Masahiro Yoshinaga,1 Akira Ohtani,1 Satoru Tsuruta,1 Tetsuya Kato,1 Eishi Higashi,1 Yukio Yamada,1 Naohiko Harada,2 and Hajime Nawata2

1Department of Internal Medicine, Chikuhou Hospital, Japan
2Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Received 17 November 1998; Revised 28 April 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: Recent studies have shown that acid-suppressive therapy increases the severity of Helicobacter pylori- associated gastritis in the corpus.

PURPOSE: To evaluate interleukin (IL)-8 production in the gastric corpus mucosa before and during acid-suppressive therapy in H pylori-infected patients.

PATIENTS AND METHODS: Ten patients with reflux esophagitis (five H pylori-positive and five H pylori-negative) were treated with omeprazole 20 mg. Serum gastrin concentrations, H pylori colonization density and mucosal IL-8 levels in the corpus were investigated at entry and two weeks after starting therapy. IL-8 levels were measured by ELISA. The organism density was determined, and scored according to area occupied by the bacterial colonies. The presence of H pylori was assessed by rapid urease testing and histological finding of gastric biopsy specimens.

RESULTS: In H pylori-positive patients, concentrations of IL-8 during therapy significantly exceeded those before therapy (36.2±6.8 versus 18.3±3.8 pg/mg protein; P<0.05) without altering H pylori density. In H pylori-negative patients, IL-8 levels were similar before and during therapy (6.1±2.7 versus 6.3±3.0 pg/mg protein). Concentrations of gastrin during therapy were significantly higher than those before therapy in all patients.

CONCLUSIONS: The results suggest that acid suppression increases mucosal IL-8 levels in H pylori-infected patients with reflux esophagitis.