Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 2001 / Article

Brief Communication | Open Access

Volume 15 |Article ID 651470 |

Susan E Natsheh, Eve A Roberts, Bo Ngan, Peter Chait, Vicky Lee Ng, "Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis", Canadian Journal of Gastroenterology and Hepatology, vol. 15, Article ID 651470, 4 pages, 2001.

Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis

Received28 Feb 2001
Accepted28 Feb 2001


Hemophagocytic lymphohistiocytosis (HLH) may manifest as neonatal liver failure characterized by hepatosplenomegaly, profound coagulopathy, ascites and hyperbilirubinemia. Marked hyperferritinemia may be present in these patients, mimicking perinatal hemochromatosis. Tissue specimens are critical in distinguishing these two diseases and in directing management. Clinical recognition and diagnosis of HLH can be difficult but are crucial for appropriate therapy and genetic counselling. Liver transplantation is absolutely contraindicated for patients with HLH but may be the only life-saving treatment modality for patients with perinatal hemochromatosis.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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