Canadian Journal of Gastroenterology and Hepatology

Canadian Journal of Gastroenterology and Hepatology / 2003 / Article

Hot Topics in Gastroenterology | Open Access

Volume 17 |Article ID 205751 |

Marc Bilodeau, "Liver Cell Death: Update on Apoptosis", Canadian Journal of Gastroenterology and Hepatology, vol. 17, Article ID 205751, 6 pages, 2003.

Liver Cell Death: Update on Apoptosis


Hepatocyte cell death is a cardinal feature of almost every liver disease. Apoptosis is a mode of cell death characterized by specific morphological and biochemical features. Over the past decade, the importance of apoptosis has been appreciated, and it is now thought to be the main mode of cell death in liver diseases. The recognition that apoptosis can be modulated by the cell itself or by the extracellular environment has given hope that treatments can be designed to modify the evolution of disease. This article presents an overview of this important phenomenon, as well as models of hepatocyte apoptosis and goals of current research. The significance of apoptosis to the pathophysiology of liver disease is discussed.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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