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Canadian Journal of Gastroenterology
Volume 18, Issue 6, Pages 407-408
Canadian Gastroenterology Elsewhere

Antineoplastic Effects of 5-Aminosalicylates and Potential Cancer Preventive Role in Inflammatory Bowel Disease

Hugh J Freeman

Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Early studies from tertiary referral centers in the United States and Europe showed that patients with long-standing and extensive inflammatory bowel disease (IBD) have an increased risk of colon cancer. It was subsequently appreciated that the degree of risk depended on the population being studied and on both genetic and environmental factors (eg diet, drugs and prior surgical treatment). Indeed, over the past decade or so, the effects of chronically administered medications, including 5-aminosalicylates (5-ASA), have been explored.