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Canadian Journal of Gastroenterology
Volume 18 (2004), Issue 11, Pages 677-680
http://dx.doi.org/10.1155/2004/763529
Brief Communication

Deadaption and Readaptation with Lactose, But No Cross-Adaptation to Lactulose: A Case of Occult Colonic Bacterial Adaptation

Andrew Szilagyi,1 Albert Cohen,1 Christina Vinokuroff,2 Darakhshan Ahman,3 Usha Nathwani,2 and Samara Yesovitch1

1Division of Gastroenterology, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada
2Departmentt of Dietetics, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada
3Institut national de la recherché scientique — Institut Armand Frappier, Centre de microbiologie et biotechnologie, Université du Québec, Pointe–Claire, Quebec, Canada

Received 22 June 2004; Accepted 4 August 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The standard 3 h breath hydrogen (3hBH2) test distinguishes lactose maldigesters from lactose digesters. However, multiple factors impact on BH2 and care is needed to exclude a priori variables. When these factors are controlled, a negative BH2 test implies lactase persistent status or lactase nonpersistent status with colonic adaptation. A case of a Sicilian man who tested negative (lactase persistent status confirmed) on an initial 50 g lactose challenge is described. It was observed that he consumed 28.1 g lactose/day before testing. He subsequently underwent five additional challenge tests in the course of the next 10 months. In four tests the dose intake of lactose was varied upon instruction, and in the fifth test a 30 g lactulose challenge was carried out. It was demonstrated that on radically decreasing lactose intake, a full lactase nonpersistent status was unmasked. Output of 3hBH2 varied inversely with daily lactose intake. Finally, at a time when he was readapted to lactose, there was no discernible adaptation to lactulose challenge. It was concluded that 'occult' colonically adapted subjects may contribute to negative BH2 tests. There is a relationship between variation in lactose intake and the results of BH2 testing. Finally, there was no cross-adaptation to lactulose challenge when lactose was used as the adapting sugar.