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Canadian Journal of Gastroenterology
Volume 19, Issue 4, Pages 251-252
Brief Communication

Crohn's Disease Defined in Three Elderly Disters

Hugh J Freeman

Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada

Received 8 November 2004; Accepted 2 March 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three elderly sisters presented with symptomatic Crohn's disease. All had ileocolic involvement, and granulomatous inflammation was documented in endoscopic biopsies or surgically resected intestinal specimens. The present report documents the unusual occurrence of very late phenotypical expression of familial ileocolic Crohn's disease. The observations presented here reflect a possible gene-based predisposition to Crohn's disease or, alternatively, disease clustering related to a commonly shared environmental factor.