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Canadian Journal of Gastroenterology
Volume 21 (2007), Issue 11, Pages 753-755
http://dx.doi.org/10.1155/2007/256031
Brief Communication

Colonic Malakoplakia in a Liver Transplant Recipient

Peter TW Kim,1 Jennifer E Davis,2 Siegfried R Erb,3 Eric M Yoshida,3 and Urs P Steinbrecher3

1Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
3Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Received 13 June 2006; Accepted 5 December 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malakoplakia is a rare inflammatory condition seen in transplant patients. There are two previously reported cases of malakoplakia involving the gastrointestinal tract in liver transplant patients. The present paper reports a case of colonic malakoplakia in a 58-year-old woman, a liver transplant recipient who was receiving immunosuppressive drugs. She presented with chronic diarrhea while on tacrolimus. There was no history of antecedent infection. Colonoscopy showed patchy mucosal edema, but no discrete yellow plaques or nodules. The diagnosis was made by colon biopsies, which showed chronic inflammation with many histiocytes containing Michaelis-Gutmann bodies. Although rare, malakoplakia is one of many potential causes of diarrhea in a transplant patient. The present case indicates that malakoplakia may be associated with chronic diarrhea, even if there are no macroscopic lesions seen during colonoscopy.