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Canadian Journal of Gastroenterology
Volume 22 (2008), Issue 2, Pages 143-148
http://dx.doi.org/10.1155/2008/645107
Original Article

Incidence and Survival for Gastric and Esophageal Cancer Diagnosed in British Columbia, 1990 to 1999

Morteza Bashash,1 Amil Shah,2,3 Greg Hislop,1,4 Angela Brooks-Wilson,5,6 Nhu Le,1,7 and Chris Bajdik1,5

1Cancer Control Research Program, BC Cancer Agency, Canada
2Medical Oncology, BC Cancer Agency, Canada
3Department of Medicine, University of British Columbia, Canada
4Department of Health Care and Epidemiology, University of British Columbia, Canada
5Canada’s Michael Smith Genome Sciences Centre, Canada
6Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
7Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

Received 14 June 2007; Accepted 4 December 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND: Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described.

METHODS: Incidence data for the period 1990 to 1999 were obtained from the BC Cancer Registry. Age-adjusted incidence and survival rates were computed by anatomical subsite, histological type and sex. All rates were standardized to the 1996 Canadian population. The estimated annual percentage change (EAPC) was used to measure incidence changes over time. Kaplan-Meier curves were used to show survival rates, and log-rank tests were used to test for differences in the curves among various groups.

RESULTS: Between 1990 and 1999, 1741 esophageal cancer cases and 3431 gastric cancer cases were registered in BC. There was an increase in the incidence of adenocarcinoma of the esophagus over time (EAPC=9.6%) among men, and of gastric cardia cancer among both women (EAPC=9.2%) and men (EAPC=3.8%). Patients with proximal gastric (cardia) cancer had significantly better survival rates than patients with cancer in the lower one-third of the esophagus. Among gastric cancers, patients with distal tumours had a significantly better survival rate than patients with proximal tumours.

DISCUSSION: The incidences of proximal gastric cancer and esophageal adenocarcinoma are increasing, and their survival patterns are different. Examining these cancers together may elucidate new etiological and prognostic factors.