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Canadian Journal of Gastroenterology and Hepatology
Volume 29, Issue 8, Pages 427-430
Original Article

Serum Endocan as a Survival Predictor for Patients with Liver Cirrhosis

Nobuyuki Toshikuni, Kazuaki Ozaki, Joseph George, and Mikihiro Tsutsumi

Department of Hepatology, Kanazawa Medical University, Ishikawa, Japan

Received 6 April 2015; Accepted 30 April 2015

Copyright © 2015 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: The relationship between endocan expression and outcome in patients with chronic liver disease is not fully understood.

OBJECTIVE: To examine whether serum endocan level is predictive of outcome in patients with liver cirrhosis.

METHODS: A total of 68 patients with liver cirrhosis were enrolled. Outcome predictors were analyzed using the Cox proportional hazards model. The overall survival rates were calculated using the Kaplan-Meier method, and differences were evaluated using the log-rank test.

RESULTS: During the median follow-up period (7.1 years), nine patients had hepatocellular carcinoma (HCC) and 10 patients died. Of the deceased patients, nine died due to hepatic decompensation or associated conditions. No significant factors were found to be predictive of the occurrence of HCC. In contrast, an elevated serum endocan level (≥2.0 ng/mL; HR 2.34 [95% CI 1.05 to 7.03]; P=0.037) and high Child-Pugh grade B/C (HR 2.65 [95% CI 1.30 to 6.89; P=0.006) were predictive of poor survival. Kaplan-Meier analysis revealed that the respective cumulative survival rates at five and 10 years were 97.1% and 87.4% in patients with serum endocan levels <2.0 ng/mL and 85.8% and 64.4% in patients with levels ≥2.0 ng/mL (P=0.009), respectively. Moreover, the cumulative survival rates were significantly different among the patient groups divided according to serum endocan level and Child-Pugh grade (P=0.002).

CONCLUSION: These findings suggest that serum endocan level may be a survival predictor for patients with liver cirrhosis.