Program and Abstracts from the Canadian Digestive Diseases Week 2016

Table 6

	PBO ()	UST 130 mg ()	UST ~6 mg/kg ()
Clinical Response
Wk 3	45 (21.5)	68 (32.5); p = 0.010	81 (38.8); p < 0.001
Wk 6	60 (28.7)	108 (51.7); Delta = 23%; p < 0.001	116 (55.5); Delta = 26.8%; p < 0.001
Wk 8	67 (32.1)	99 (47.4); p < 0.001	121 (57.9); p < 0.001
Clinical Remission
Wk 3	24 (11.5)	33 (15.8); p = 0.199	48 (23.0); p = 0.002
Wk 6	37 (17.7)	60 (28.7); p = 0.007	73 (34.9); p < 0.001
Wk 8	41 (19.6)	64 (30.6); Delta = 11.0%; p = 0.009	84 (40.2); Delta = 20.6%; p < 0.001

(%); reduction in CDAI; CDAI < 150; weight-range based UST doses ~6 mg/kg: 260 mg (weight ≤ 55 kg), 390 mg (weight > 55 kg and ≤ 85 kg), 520 mg (weight > 85 kg); primary endpoint.