Study Number of Patients Sex (M/F) Age Tumor stage Multiple tumors ( Presence of portal vein tumor thrombus ( Tumor capsule completed/uncompleted ( Tumor size (cm) HBV DNA level (log copies/mL) ALT (IU/L) Cirrhosis ( Type of treatment Follow-up duration (months) Quality score
Li et al. 2010 [16 ] 79 (43 versus 36) 34/9 versus 30/6 46 versus 45 TNM: 9/17/17 versus 4/10/12 N/A 10 versus 13 N/A 7.1 versus 8.5 N/A N/A 24 versus 25 Resection 12 versus 12 6
Kubo et al. 2007 [17 ] 24 (14 versus 10) 10/4 versus 7/3 55 versus 55 TNM: 2/7/5 versus 3/2/5 5 versus 5 4 versus 4 N/A 2.4 versus 2.8 N/A 53 versus 56 N/A Resection 37 versus 7 7
Chuma et al. 2009 [24 ] 84 (20 versus 64) 14/6 versus 50/14 56 versus 56 TNM: 9/10/1 versus 22/34/8 5 versus 16 N/A N/A 1.7 versus 2.0 N/A 43 versus 30 11 versus 31 Resection and RFA 34 versus 53 8
Kuzuya et al. 2007 [22 ] 49 (16 versus 33) 14/2 versus 27/6 60 versus 61 TNM: 12/3/1 versus 13/16/4 N/A N/A N/A N/A 6.2 versus 4.1 57 versus 54 N/A Resection and RFA 38 versus 33 7
Koda et al. 2009 [21 ] 36 (22 versus 14) 24/6 versus 15/5 59 versus 60 TNM: 19/20/11/0 N/A N/A N/A N/A N/A 78 versus 54 N/A RFA, PEI, and TAE 59 7
Hann et al. 2014 [26 ] 25 (16 versus 9) 14/2 versus 16/0 57 (20–73) versus 53 (46–60) N/A 0/0 N/A N/A 2.65 (1–7) versus 3 (1–6.9) 5.4 (2.7–8.4) versus 6.9 (2.9–7.2) N/A N/A Local ablation 53 (48–66) versus 57 (20–73) 9
Ke et al. 2013 [27 ] 478 (141 versus 337) 129/12 versus 284/53 49 versus 50 BCLC: 107/23/11 versus 256/60/21 39 versus 97 N/A 84/57 versus 163/174 N/A N/A 39 (2–504) versus 35 (2–341) 82 versus 79 Resection 24 (2–65) versus 24 (0–73) 6
Huang et al. 2013 [8 ] 1040 (86 versus 175) 758/107 versus 156/19 51 versus 52 N/A N/A N/A N/A 5.2 versus 5.3 N/A 58 versus 48 N/A Resection 42 (4–72) 7
Yin et al. 2013 [20 ] 617 (215 versus 402) 194/21 versus 336/66 50 versus 50 BCLC: 6/159/50 versus 6/296/98 31 versus 51 30 versus 62 87/128 versus 158/244 N/A 4.51 versus 3.82 N/A 101 versus 144 Resection 24 (median) 8
Yin et al. 2013 [20 ] 163 (81 versus 82) 74/7 versus 70/12 48 versus 49 BCLC: 4/67/10 versus 2/58/22 10 versus 18 3 versus 6 38/43 versus 22/50 N/A 4.88 versus 4.57 N/A 20 versus 23 Resection 40 (median) 3
Urata et al. 2012 [28 ] 59 (46 versus 13) 34/12 versus 8/5 57 versus 58 N/A 8 versus 13 N/A N/A 2.8 versus 3.4 4.7 versus 6.1 47 versus 58 21 versus 4 Resection 37 (2–132) 7
Chan et al. 2011 [33 ] 136 (42 versus 94) 31/11 versus 74/20 57 (36–83) versus 55 (22–81) AJCC: 11/14/16 versus 28/18/48 N/A N/A N/A 9.3 (1–28) versus 9.0 (2–21) N/A 58 (12–182) versus 43 (13–393) 31 versus 53 Resection N/A 7
Chong et al. 2015 [4 ] 404 (254 versus 150) 222/32 versus 125/25 56 (32–80) versus 55 (27–81) AJCC: 16/50/34/2 versus 97/27/26/0 56 versus 32 N/A N/A N/A N/A 43 (10–2452) versus 44 (14–262) 168 versus 79 Resection 39 (0–164) versus 43 (0–151) 8
Huang et al. 2015 [19 ] 200 (100 versus 100) 90/10 versus 89/11 50 versus 51 BLCL (0/A): 8/60 versus 8/59 N/A N/A 70/30 versus 69/31
4.9 vs/5.1 N/A 53 versus 51 N/A Resection 60 (4–70) 4
Wu et al. 2012 [25 ] 4569 (518 versus 4051) 435/83 versus 3335/716 54 versus 55 N/A N/A N/A N/A N/A N/A N/A 252 versus 1568 Resection 32 versus 26 8 Nishikawa et al. 2014 [34 ] 97 (65 versus 32) 47/18 versus 20/12 56 versus 61 TNM: 16/33/16 versus 7/16/9 25 versus 9 N/A N/A 2.8 versus 3.2 N/A 53 versus 40 38 versus 15 RFA and PEI 59 versus 48 7
