Canadian Journal of Gastroenterology and Hepatology / 2016 / Article / Tab 1

Review Article

Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials

Table 1

Characteristics of five included studies.

StudyYearCountryMethodPancreatic enzymeDuration

Halgreen et al. [6]1986DenmarkDouble-blind randomized crossoverEnteric-coated Pancrease (lipase 20,000, amylase 20,000, and protease 25,000), two capsules at meals and one capsule with snacks2 weeks

Isaksson and Ihse [7]1983SwedenDouble-blind randomized crossoverPankreon (granulated pancreatic enzymes)One week

Malesci et al. [8]1995ItalyDouble-blind randomized crossoverEnteric-coated Pancrex-Duo (lipase 13,000 UI, amylase 43,570 UI, and protease 34,375 IU)4 months

Mossner et al. [9]1992GermanyDouble-blind randomized crossoverEnteric-coated Panzytrat (20,000 IU; 5 × 2 capsules/day; proteases/capsule 1,000 IU)2 weeks

O’Keefe et al. [10]2001South AfricaRandomized, parallel groupEnteric-coated capsules (four capsules with meals, two with snacks; content/capsule: lipase 10,000 USP units, protease 37,500 units, and amylase 33,200 units)2 weeks

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.