Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials

Table 1

Characteristics of five included studies.

Study	Year	Country	Method	Pancreatic enzyme	Duration
Halgreen et al. [6]	1986	Denmark	Double-blind randomized crossover	Enteric-coated Pancrease (lipase 20,000, amylase 20,000, and protease 25,000), two capsules at meals and one capsule with snacks	2 weeks
Isaksson and Ihse [7]	1983	Sweden	Double-blind randomized crossover	Pankreon (granulated pancreatic enzymes)	One week
Malesci et al. [8]	1995	Italy	Double-blind randomized crossover	Enteric-coated Pancrex-Duo (lipase 13,000 UI, amylase 43,570 UI, and protease 34,375 IU)	4 months
Mossner et al. [9]	1992	Germany	Double-blind randomized crossover	Enteric-coated Panzytrat (20,000 IU; 5 × 2 capsules/day; proteases/capsule 1,000 IU)	2 weeks
O’Keefe et al. [10]	2001	South Africa	Randomized, parallel group	Enteric-coated capsules (four capsules with meals, two with snacks; content/capsule: lipase 10,000 USP units, protease 37,500 units, and amylase 33,200 units)	2 weeks