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Canadian Journal of Gastroenterology and Hepatology
Volume 2017, Article ID 6238106, 11 pages
https://doi.org/10.1155/2017/6238106
Review Article

Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

1Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore 54590, Pakistan
2Cell and Applied Molecular Biology (CAMB), University of the Punjab, Q-A Campus, Lahore 54590, Pakistan

Correspondence should be addressed to Nadeem Sheikh; moc.oohay@77meedan_s

Received 13 February 2017; Accepted 19 April 2017; Published 10 May 2017

Academic Editor: José L. Mauriz

Copyright © 2017 Naz Fatima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect.