Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Figure 3

Schematic diagram showing progression of HCC by TLR4 pathway. Gut permeability alterations and LPS translocation to liver cause liver damage and activation of TLR4 signaling in HSC and hepatocytes result in ECM makeover, fibrogenesis, and exudation of EGF leading to HCC.