Review Article

A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplant for Clostridium difficile Infection in Immunocompromised Patients

Table 1

Summary of included articles.

Author, YearArticle typeN patients includedImmunocompromisedFMT deliveryN
transplant
Stool (g or volume (mL per transplantDonor relationshipAE

Aas, 2003 [13]Case series1LeukemiaNG Tube130 g/25 mlNRNo

Aratari, 2015 [14]Case report1IBD on ISColonoscopy1150 gURNo

Bilal, 2015 [15]Case report1Liver and kidney transplant on tacrolimusColonoscopy1180 mlRNo

Blackburn, 2015 [16]Case report1LeukemiaColonoscopy1NRNRNo

de Castro, 2015 [17]Case Report1ALL s/p HSCTUpper Endoscopy1NRNRNo

Duplessis, 2012 [18]Case report1CD on ISUG Upper Endoscopy175 g/200 mlRNo

Ehlermann, 2014 [19]Case report1Heart transplantUpper Endoscopy1100 mlRNo

Elopre, 2013 [20]Case series2AIDS, DM + AIDSUpper Endoscopy130 g/25 mlRNo

Fischer, 2016 [21]Cohort101Multiple definedColonoscopy1NRNRNR

Friedman-Moraco, 2014 [22]Case series2SOTUpper Endoscopy and Colonoscopy230 g/80-325 mlRYes

Garborg, 2010 [23]Case series1AMLUpper Endoscopy150-100 g/200 mlRNo

Gathe, 2016 [24]Case report1HIVColonoscopy, Enema and Nasogastric tube4NRRNo

Guiterrez-Delgado, 2016 [25]Case series1Acute leukemiaColonoscopy2NRURNo

Gweon, 2015 [26]Case report1Thyroid cancerColonoscopy and Upper Endoscopy175 gURNo

Hirsch, 2015 [27]Case series5Lymphoma, AML, Renal cell CA, ISOral (ingested1-42.3 g (6-22 capsules)URYes

Hourigan, 2015 [28]Case series3IBD on ISColonoscopy192 gRNo

Kelly, 2014 [29]Case seriesIS, SOT, Severe/end stage chronic disease, Cancer, HIVColonoscopy#1-2NRNRYes

Khoruts, 2016 [30]Case series38SOT, ISColonoscopy1NRNRNR

Kronman, 2014 [31]Case series3IBD on ISNG Tube1 30-60 mlRNo

Laszlo, 2016 [32]Case series1UC on ISColonoscopy1150 mlRYes

Lee, 2014 [33]Case report1Liver transplantUpper Endoscopy2NRRYes

Lee CH, 2014 [34]Case series3Renal transplantEnema1-4100 mlURNo

Loke, 2016 [35]Case report1Specific Antibody Deficiency (SADColonoscopy150 g/500 mlRNR

Mandalia, 2016 [36]Case series37HIV, AIDS, malignancy, ISNR1-3NRNRYes

Mattila, 2012 [37]Case series3Lung transplantColonoscopy1-2100 mlR and URNo

Mittal, 2015 [38]Case report1Diffuse large B cell non-Hodgkin’s lymphoma +UCEnema2NRNRYes

Neemann, 2015 [39]Case report1ALL s/p HSCTUpper Endoscopy130 mlRNR

Ott, 2017 [40]Case series3Kidney transplant, HIV, Colon CancerUpper Endoscopy1NRR and URNo

Pathak, 2014 [41]Case series3Adenocarcinoma left colon, Renal transplant, CancerColonoscopy16-8 teaspoons, 40- 500mlRNo

Pierog, 2014 [42]Case series2IBD on ISColonoscopy160 mlRYes

Porter, 2014 [43]Case report1B cell CLLUpper Endoscopy650 gURNR

Quera, 2013 [44]Case report1CD on ISColonoscopy1NRNRYes

Ramay, 2015 [45]Case report1Heart transplantColonoscopy2250 mlURNo

Ray, 2014 [46]Case series2MultipleColonoscopy160 mlRNo

Rubin, 2012 [47]Case series15Malignant diseaseUpper Endoscopy130 g/25 mlRNo

Russell, 2014 [48]Case series1UC on ISColonoscopy130-40 g/250 mlRYes

Schunemann, 2013 [49]Case report1AIDSColonoscopy and Upper Endoscopy2NRRNo

Silverman, 2010 [50]Case series3Lymphoma, liver transplantEnema150 mlRYes

Stripling, 2015 [51]Case report1Cardiac, kidney transplant on ISUpper Endoscopy1NRRNo

Trubiano, 2014 [52]Case report1Diffuse large B cell lymphomaUpper Endoscopy2260 mlRNo

Webb, 2016 [53]Case series5HSCTNJ tube125-100 gNRYes

Weingarden, 2013 [54]Case series1Metastatic Ovarian cancerColonoscopy1NRURYes

Yoon, 2010 [55]Case series2Colon cancer, Breast cancerColonoscopy1NRRNo

Zainah, 2012 [56]Case report1UC on ISColonoscopy1300 mlRNo

AE= adverse events; ALL= acute lymphocytic leukemia; AML= acute myeloid leukemia; CA= cancer; CD=Crohn’s disease; CLL= chronic lymphocytic leukemia; E= enema; HIV= human immunodeficiency virus: IBD= inflammatory bowel disease: IS= immunosuppressant; HSCT= hematopoietic stem cell transplant; LTE= letter to editor; NG= nasogastric tube; NR= not reported or no separate patient level data on immunocompromised patients; R= related (genetically or household; SOT= solid organ transplant; UC= ulcerative colitis; UG= upper gastrointestinal endoscopy; and UR= unrelated
= more IC patients but only including those with separate data that we could match to IC status, outcome, and AE
#= article reports where most centers used colonoscopy; possibly some included patients had other route of delivery.