Canadian Journal of Gastroenterology and Hepatology / 2018 / Article / Tab 1

Research Article

Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry

Table 1

Baseline demographic characteristics.

All
(N = 3,087)
Cirrhosis
(n = 630)

Age distribution, n (%
 ≤50 y479 (16)190 (30)
 51–64 y937 (30)339 (54)
 65–74 y587 (19)81 (13)
 ≥75 y1,084 (35)20 (3)
Men, n (%1,558 (51)419 (67)

Race distribution: US only, n (%
 White1,927 (74)455 (72)
 African-American309 (12)58 (9)
 Asian57 (2)13 (2)
 Other154 (6)53 (9)
 Unknown149 (6)51 (8)
Mean initial [Na+] ± SD, mEq/123.6 ± 5.5124.1 ± 5.0
Mean initial BUN ± SD, mg/d20.8 ± 16.825.5 ± 18.8
Mean initial creatinine ± SD, mg/d1.1 ± 0.731.28 ± 0.85
Initial BUN:creatinine 19.4 ± 9.419.8 ± 8.6

Prior HN, n (%
 Yes909 (29)240 (38)
 No1,176 (38)178 (28)
 Unknown1,001 (32)212 (34)

HN at admission, n (%
 Yes2,532 (82)549 (87)
 No531 (17)81 (13)
 Unknown24 (1)0 (0)

Primary physician specialty, n (%)
 Nephrologist104 (3)8 (1)
 Endocrinologist108 (4)0
 Cardiologist321 (10)7 (1)
 Hepatologist260 (8)246 (39)
 Oncologist111 (4)11 (2)
 Generalist1,844 (60)315 (50)
 Other338 (11)43 (7)

HN subspecialist consulted, n (%
 No1989 (64)501 (80)
 Yes1,096 (36)129 (21)

Abbreviations: BUN, blood urea nitrogen; CHF, congestive heart failure; HN, hyponatremia; [Na+], sodium concentration; SD, standard deviation; SIADH, syndrome of inappropriate antidiuretic hormone secretion.
vs CHF and cirrhosis, and CHF vs cirrhosis: P <0.001.
vs CHF: P = 0.79; and SIADH and CHF vs cirrhosis: P <0.001.
vs CHF and cirrhosis: P <0.001; CHF vs cirrhosis: P = 0.01.
vs CHF and cirrhosis: P <0.001; and CHF vs cirrhosis: P = 0.05.
during previous hospital admission in prior 12 months.
missing for 24 patients in All, 19 in SIADH, and 4 in CHF populations; SIADH vs CHF: P = 0.04; SIADH vs cirrhosis: P = 0.001; and CHF vs cirrhosis: P <0.001.
vs CHF and cirrhosis: P <0.001; and CHF vs cirrhosis: P = 0.01.
specialist defined as nephrologist or endocrinologist.
171 patients without a diagnosis of SIADH, cirrhosis, or CHF.

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