Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry

Table 3

Patients with [Na⁺] ≥5 mmol/L in response to initial and secondary .

	Day 2; Response	Day 3; response	Final response
Initial therapy, n (%)
NST	9 (27)	11 (33)	13 (39)
FR	29 (27)	38 (36)	42 (39)
NS	54 (45)	61 (51)	62 (52)
HS	7 (78)	7 (78)	7 (78)
TO	10 (48)	15 (71)	17 (81)
Secondary therapy, n (%)
NST	5 (36)	5 (36)	5 (36)
FR	15 (31)	18 (37)	18 (37)
NS	9 (29)	10 (32)	10 (32)
HS	10 (100)	10 (100)	10 (100)
TO	15 (58)	17 (65)	18 (68)

with initial moderate or severe hyponatremia.
Initial therapy P <0.05 for Day 2 response: no specific therapy (NST) vs hypertonic saline (HS), and fluid restriction (FR) vs HS and isotonic saline (NS); Day 3 response: NST vs HS and tolvaptan (TO); FR vs HS, NS, and TO: final response: NST vs TO, FR vs HS and TO, and NS vs TO.