Canadian Journal of Gastroenterology and Hepatology / 2018 / Article / Tab 3

Review Article

Laparoscopic versus Open Surgery for Hepatocellular Carcinoma: A Meta-Analysis of High-Quality Case-Matched Studies

Table 3

Overall outcomes of the meta-analysis.

OutcomesStudies No. Sample sizeHeterogeneity
(, )
ModelOverall effect size95% CI of overall effect
LHOH

Operation time (min)2012551671<0.01, 87%R0.28
 Minor hepatectomy8321355<0.01, 78%R0.17
 Mixed hepatectomy98311213<0.01, 83%R0.29
 Major hepatectomy31031030.05, 67%R<0.01
Blood loss (mL)1711281425<0.01, 92%R−157.33~−29.09<0.01
 Minor hepatectomy72783120.39, 5%R−98.41~−54.01<0.01
 Mixed hepatectomy774710100.05, 52%R−294.57~−131.31<0.01
 Major hepatectomy31031030.88, 0%R0.88
Transfusion1497913520.90, 0%F0.03
 Minor hepatectomy41211550.49, 0%F0.22
 Mixed hepatectomy878811270.86, 0%F0.06
 Major hepatectomy270700.28, 15%F0.70
Hospital stay (days)2012551671<0.01, 80%R−3.63~−2.08<0.01
 Minor hepatectomy8321355<0.01, 76%R−4.23~−1.63<0.01
 Mixed hepatectomy983112130.01, 58%R−3.95~−1.76<0.01
 Major hepatectomy31031030.15, 47%R−4.60~−0.92<0.01
Morbidity20125516710.28, 14%F<0.01
 Minor hepatectomy83213550.29, 17%F<0.01
 Mixed hepatectomy983112130.26, 21%F<0.01
 Major hepatectomy31031030.21, 37%F<0.01
Severe complications18119614760.88, 0%F<0.01
 Minor hepatectomy72883050.96, 0%F0.04
 Mixed hepatectomy880510680.44, 0%F<0.01
 Major hepatectomy31031030.35, 6%F0.05
Mortality978910260.88, 0F0.05
 Minor hepatectomy31041210.34, 7F0.21
 Mixed hepatectomy56538730.84, 0F0.18
 Major hepatectomy13232Not applicableF0.50
Tumor size (cm)1912291645<0.01, 57%R0.09
 Minor hepatectomy83213550.76, 0%R0.48
 Mixed hepatectomy880511870.50, 0%R0.28
 Major hepatectomy3103103<0.01, 92%R0.13
Margin distance (cm)115016940.14, 47%R<0.01
 Minor hepatectomy51862200.06, 56%R0.03
 Mixed hepatectomy52824410.15, 41%R0.02
 Major hepatectomy13333Not applicableR0.18
R0 resection14101014090.70, 0%F0.37
 Minor hepatectomy62402570.80, 0%F0.23
 Mixed hepatectomy773811200.47, 0%F0.13
 Major hepatectomy13232Not applicableF0.56

WMD: weighted mean difference; RR: risk ratio; F: fixed; R: random.