Research Article
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
Table 2
Effect of antidepressant use on subsequent development of IBD activity and according to anxiety and depression scores at baseline.
| | | Antidepressant Use:
All Patients | Antidepressant Use:
Normal Anxiety and Depression Scores at Baseline | Antidepressant
Use: Abnormal Anxiety or Depression Scores at Baseline | Antidepressant
Use: Abnormal Anxiety Scores at Baseline | Antidepressant
Use: Abnormal Depression Scores at Baseline | | No | Yes | P value | No | Yes | P value | No | Yes | P value | No | Yes | P value | No | Yes | P value |
| | Glucocorticosteroid prescription or flare of disease activity () | 121/279
(43.4) | 21/52
(40.4) | 0.69 | 82/203
(40.4) | 10/25
(40.0) | 0.97 | 38/73
(52.1) | 11/27
(40.1) | 0.32 | 35/65
(53.8) | 10/26
(38.5) | 0.19 | 9/21 (42.9) | 6/14 (42.9) | 1.00 |
| | Escalation of medical therapy in response to uncontrolled disease activity () | 120/279
(43.0) | 17/52
(32.7) | 0.17 | 85/203
(41.9) | 10/25
(40.0) | 0.86 | 34/73
(46.6) | 7/27 (25.9) | 0.06 | 31/65
(47.7) | 6/26 (23.1) | 0.03 | 8/21 (38.1) | 5/14 (35.7) | 0.89 |
| | Hospitalisation due to disease activity () | 38/279
(13.6) | 5/52
(9.6) | 0.43 | 26/203
(12.8) | 4/25 (16.0) | 0.66 | 12/73
(16.4) | 1/27
(3.7) | 0.09 | 11/65
(16.9) | 1/26
(3.8) | 0.10 | 2/21
(9.5) | 0/14
(0) | 0.23 |
| | Intestinal resection () | 15/279
(5.4) | 4/52
(7.7) | 0.51 | 8/203
(3.9) | 3/25 (12.0) | 0.08 | 7/73
(9.6) | 1/27
(3.7) | 0.34 | 6/65
(9.2) | 1/26
(3.8) | 0.38 | 2/21
(9.5) | 0/14
(0) | 0.23 |
| | Any adverse outcome () | 148/279
(53.0) | 24/52
(46.2) | 0.36 | 102/203
(50.2) | 12/25
(48.0) | 0.83 | 45/73
(61.6) | 12/27
(44.4) | 0.12 | 42/65
(64.6) | 11/26
(42.3) | 0.05 | 10/21
(47.6) | 6/14 (42.9) | 0.78 |
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