The Effect of Antidepressants on the Course of Inflammatory Bowel Disease

Table 3

Effect of antidepressant or SSRI use on subsequent IBD activity based on univariate cox regression analysis.

	Glucocorticosteroid prescription or flare of disease activity		Escalation of Medical Therapy in Response to Uncontrolled Disease Activity		Hospitalisation due to Disease Activity		Intestinal resection
	Hazard ratio; (95 CI)	P value	Hazard ratio; (95 CI)	P value	Hazard ratio; (95 CI)	P value	Hazard ratio; (95 CI)	P value
Antidepressant use: all patients	0.76; (0.47-1.22)	0.25	0.59; (0.35-1.00)	0.05	0.59; (0.231.50)	0.26	1.15; (0.373.53)	0.81
Antidepressant use: normal anxiety and depression scores at baseline	0.77; (0.38-1.54)	0.77	0.72; (0.36-1.44)	0.35	1.01; (0.352.93)	0.98	2.15; (0.558.50)	0.27
Antidepressant use: abnormal anxiety or depression scores at baseline	0.63; (0.32-1.23)	0.17	0.47; (0.21-1.05)	0.07	0.20; (0.031.57)	0.13	0.37; (0.053.04)	0.36
SSRI use: all patients	0.74; (0.41-1.31)	0.30	0.47; (0.24-0.93)	0.03	0.35; (0.081.46)	0.15	0.86; (0.193.85)	0.84
SSRI use: normal anxiety and depression scores at baseline	0.76; (0.31-1.91)	0.56	0.49; (0.18-1.37)	0.18	0.87; (0.203.75)	0.86	2.39; (0.4712.2)	0.29
SSRI use: abnormal anxiety or depression scores at baseline	0.58; (0.27-1.26)	0.17	0.43; (0.17-1.11)	0.08	0.03; (0.0010.1)	0.24	0.03; (0.0073.9)	0.39