The Frequency of Clinic Visits Was Not Associated with Medication Adherence or Outcome in Children with Inflammatory Bowel Diseases

Table 3

(a) Univaried description of independent categorical variables and adherence

Categorical variables	Immunomodulators		5-ASA		Biologics		Blood work adherence
	Number of observations per yr over 2 years	Number with >80% adherence rate (%)	Number of observations per yr over 2 years	Number with >80% adherence rate (%)	Number of observations per yr over 2 years	Number with >80% adherence rate (%)	Number of observations per yr over 2 years	Number with >80% adherence rate (%)
Total	160	91 (57)	72	37 (51)	80	65 (81)	250	102 (41)
Sex
Female	69	38 (55)	37	20 (54)	22	20 (91)	109	42 (39)
Male	91	53 (58)	35	17 (49)	58	45 (76)	141	60 (43)
Disease type
Crohn’s	120	68 (57)	18	10 (56)	63	51 (81)	159	64 (40)
Ulcerative colitis	40	23 (58)	54	27 (50)	17	14 (82)	91	38 (41)
Disease activity severity
Mild	52	29 (56)	31	11 (35)	14	11 (79)	92	36 (39)
Moderate	81	46 (57)	31	20 (65)	44	35 (80)	112	49 (44)
Severe	27	16 (59)	10	6 (60)	21	18 (86)	44	15 (34)
Exacerbation
No	126	74 (59)	52	28 (54)	64	52 (81)	202	76 (38)
Yes	34	17 (50)	20	9 (45)	16	13 (81)	48	26 (54)
Address
Rural	57	31 (54)	30	10 (33)	24	21 (88)	88	29 (33)
Urban	103	60 (58)	42	27 (64)	56	44 (79)	162	73 (45)
Clinic visits per year
0 (0-1 visit)	41	23 (56)	24	12 (50)	20	17 (85)	81	24 (30)
1 (2-3 visits)	41	21 (51)	18	9 (50)	17	16 (94)	66	27 (41)
2 (>3 visits)	78	47 (60)	30	16 (53)	43	32 (74)	103	51 (50)

(b) Univaried description of adherence and independent continuous variables. Adherence is defined as taking more than 80% of medication

Continuous variables	Age (yrs) of adherent patients	Age (yrs) of nonadherent patients	Number of clinic visits per year of adherent patients	Number of clinic visits per year of nonadherent patients	Duration of disease (yrs) of those adherence	Duration of disease (yrs) of those; nonadherent
Immunomodulators
observations	91	69	91	69	91	69
Median	11.9	11.5	3	2	2.3	3.64
IQR	9.06 to 13.80	8.80 to 13.32	1.00 to 4.00	1.00 to 4.00	1.90 to 4.35	1.30 to 7.25
Mean	10.95	10.59	2.88	2.79	2.88	2.8
std. Dev.	3.79	4.07	2.11	1.91	2.11	1.91
5-ASA
observations	37	35	37	35	37	35
Median	13.18	10.99	2	2	2.4	2.92
IQR	7.47, 14.45	6.88, 13.18	1.00 to 3.00	1.00 to 4.00	2.00 to 3.25	1.88 to 4.43
Mean	11.12	10.46	2.7	2.69	3.26	3.63
std. Dev.	4.87	3.74	2.25	2.21	2.25	2.6
Biologics
observations	65	15	65	15	65	15
Median	11.20	11.19	2.00	3.00	3.76	5.52
IQR	6.75 to 13.37	9.45 to 13.05	1.00 to 4.00	2.00 to 4.00	2.05 to 6.80	2.30 to 6.04
Mean	10.29	11.02	2.9	2.8	4.77	4.62
std. Dev.	4.14	2.48	2.06	1.47	3.26	1.98
Blood work
observations	102	148	102	148	102	148
Median	12.27	10.7	2.5	2	2.73	3.7
IQR	8.36 to 13.73	7.10 to 13.05	2.00 to 4.00	1.00 to 3.00	1.90 to 4.51	2.2 to 6.80
Mean	11.12	9.84	2.9	2.21	3.45	4.71
std. Dev.	3.9	4.01	1.89	1.82	2.33	3.03