The Frequency of Clinic Visits Was Not Associated with Medication Adherence or Outcome in Children with Inflammatory Bowel Diseases

Table 4

(a) Univariate analysis of factors that were associated with medications and blood work adherence. (1 = reference)

Variables	Univaried
	Immunomodulators			5-ASA			Biologics			Blood work
	odd	95% CI	value	odd	95% CI	value	odd	95% CI	value	odd	95% CI	value
Age
Year	1.01	0.91, 1.11	0.83	1.04	0.91, 1.18	0.56	0.95	0.85, 1.06	0.37	1.09	1.00, 1,17	0.04
Sex
Female	1			1			1			1
Male	1.03	0.42, 2.51	0.95	0.8	0.29, 2.29	0.69	0.4	0.08, 1.65	0.19	1.1	0.64, 2.04	0.66
Disease type
Crohn’s	1			1			1			1
Ulcerative colitis	1.02	0.43, 2.41	0.96	0.8	0.23, 2.55	0.67	1.1	0.30, 4.07	0.89	1.1	0.58, 1.95	0.84
Duration of disease
Each year diagnosed	0.83	0.71, 0.97	0.02	0.9	0.76, 1.14	0.52	1	0.88, 1.17	0.81	0.8	0.73, 0.96	0.01
Disease severity
Mild	1			1			1			1
Moderate	1.07	0.44, 2.62	0.88	3.2	1.04, 9.88	0.04	1.1	0.28, 4.03	0.93	1.2	0.64, 2.34	0.54
Severe	1.12	0.39, 3.26	0.83	2.6	0.49, 13.6	0.26	1.6	0.23, 11.5	0.62	0.8	0.32, 1.99	0.63
Exacerbation
No	1			1			1			1
Yes	0.94	0.46, 1.94	0.88	0.7	0.22, 2.21	0.53	1.1	0.24, 4.63	0.94	2	1.08, 3.59	0.03
Address
Rural	1			1			1
Urban	1.09	0.49, 2.42	0.84	3.5	1.18, 10.56	0.02	0.5	0.13, 1.91	0.32	1.6	0.87, 3.40	0.125
Clinic visits per year
0 (0-1 visit)	1			1			1			1
1 (2-3 visits)	0.84	0.41, 1.56	0.58	1.2	0.32, 4.26	0.82	2.9	0.27, 3.16	0.38	1.13	0.58, 2.24	0.71
2 (>3 visits)	0.95	0.55, 1.63	0.39	1.1	0.30, 4.33	0.85	0.5	0.12, 2.06	0.34	1.30	0.70, 2.45	0.05

(b) Multivariate analysis of factors that were significantly associated with medications and blood work adherence (1 = reference).

Multivariable analysis
Variables	Odd	95% CI	value
	Immunomodulators
Disease duration
Year	0.82	0.70, 0.97	0.02
Sex
Female	1
Male	1.02	0.42, 2.51	0.06
	5-ASA
Disease severity
Mild	1
Mod	3.2	1.09, 9.53	0.03
Severe	3.0	0.46, 23.8	0.24
Address
Rural	1
Urban	3.6	1.20, 11.0	0.02
	Blood work
Disease Duration
Year	0.86	0.74, 0.99	0.04
Exacerbation
	1
	1.7	0.92, 3.29	0.09