Review Article
Chronic Hepatitis C Association with Diabetes Mellitus and Cardiovascular Risk in the Era of DAA Therapy
Table 1
Studies reporting the changes of fasting glucose, HbA1C, and antidiabetic treatment after DAA treatment.
| Author | Country | Patients | Genotype | Treatment | Decrease of the fasting glucose during or after DAA treatment | Decrease of the HbA1C during or after DAA treatment | Proportion of patients with the reduction of antidiabetic treatment |
| Tran,2017 [54] | Multi- ethnic | General HCV population, 25.4% prediabetes 5.9% T2DM | Genotype 1 | Paritaprevir/ ritonavir + dasabuvir + ombitasvir | Yes, in all patients, patients with prediabetes and T2DM | NA | NA |
| Ikeda, 2017 [55] | Japan | T2DM | Genotype 1b | Sofosbuvir + ledipasvir | NA | Yes | NA |
| Meissner, 2015 [56] | USA | T2DM | Genotype 1 | Sofosbuvir + ribavirin | NA | Yes | NA |
| Hum [57] | USA | T2DM | Mostly genotype 1 | Sofosbuvir + simeprevir or Sofosbuvir + ledipasvir or Paritaprevit/ritonavir + dasabuvir + ombitasvir | NA | Yes | 9% |
| Morales, 2016 [58] | USA | T2DM | Mostly genotype 1 | Only sofosbuvir based | NA | Yes | 25% |
| Ciancio, 2018 [59] | Italy | T2DM | Mostly genotype 1 | Mostly sofosbuvir based | Yes | Yes | 21% |
| Fabrizio, 2017 [60] | Italy | T2DM | Mostly genotype 1 | Mostly sofosbuvir based | Yes | NA | NA |
| Pavone, 2016 [61] | Italy | T2DM | Mostly genotype 1 | Mostly sofosbuvir based | Yes | Yes | 23% |
| Abdel Alem, 2017 [62] | Egypt | T2DM | Mostly genotype 4 | Only sofosbuvir based | Yes | Yes | NA |
| Dawood, 2017 [63] | Egypt | T2DM | Genotype 4 | Sofosbuvir + daclatasvir | Yes | Yes | 27% |
| El Sagher, 2018 [64] | Egypt | T2DM | Genotype 4 | Sofosbuvir + simeprevir | Yes | NA | NA |
| Beig, 2018 [65] | New Zealand | LTx patients, only patients without antidiabetic treatment | Mostly genotype 1 | Mostly sofosbuvir based | yes | Yes | 40% |
| Chaudhury, 2017 [66] | USA | General population, 31% HIV positive, 17%T2DM | Genotype 1 | Multiple DAA | NA | No | 3% |
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NA: not available; T2DM: type 2 diabetes mellitus.
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