Research Article

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Figure 1

Endoscopic stenting of the bile duct differentially affects the serum (a) and urine (b) bile acid-glucuronide profiles in patients suffering from biliary obstruction. Serum ((a); ) and urine ((b); ) samples drawn before (pre) and after (post) endoscopic biliary stenting from patients with stenosed bile ducts were analyzed for their concentrations in 11 bile acid-glucuronide species using LC-MS/MS. Results represent the mean concentration ± SEM and are expressed as nM. values were determined by the Wilcoxon matched-pairs signed-rank test. ; ; . ns: not significant.