Research Article

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Table 1

Summary of the correlation studies between serum and urine bile acid-glucuronide profiles.

Urine levelsBefore stentingAfter stentingResponse
(; value)(; value)(; value)

CDCA-3G0.10; 0.300.02; 0.670.25; 0.10
CDCA-24G0.01; 0.690.05; 0.500.02; 0.63
CA-24G0.32; 0.050.51; 0.010.07; 0.42
LCA-3G0.00; 0.970.19; 0.150.01; 0.81
LCA-24G0.14; 0.220.47; 0.010.42; 0.02
DCA-3G0.82; <0.00010.14; 0.230.01; 0.71
DCA-24G0.06; 0.430.16; 0.190.58; 0.004
HDCA-6G0.29; 0.070.31; 0.060.35; 0.04
HDCA-24G0.00; 1.000.05; 0.470.03; 0.59
HCA-6G0.29; 0.070.15; 0.200.67; 0.001
HCA-24G0.00; 0.830.27; 0.080.04; 0.54

Correlation analyses were performed using the Spearman rank-order correlation (), and values for comparisons are indicated. Response is calculated as the difference between post- and prestenting values. CA: cholic acid; CDCA: chenodeoxycholic acid; DCA: deoxycholic acid; HCA: hyocholic acid; HDCA: hyodeoxycholic acid; LCA: lithocholic acid; G: glucuronide.