Research Article
Noninvasive Predictors of High-Risk Varices in Patients with Non-Cirrhotic Portal Hypertension
Table 1
Demographics of study participants. HRV, high risk varices; LRV; low risk varices; NRH, nodular regenerative hyperplasia; CHF, congenital hepatic fibrosis; PVT, portal vein thrombosis; OGD, oesophogastroduodenoscopy; MELD, Model for End-stage Liver Disease score; APRI, AST to platelet ratio index; LSM, liver stiffness measurement. Unless otherwise stated, values are median (IQR).
| | Patient demographics | All patients | With HRV | Without HRV | P value | | (n = 44) | (n = 15) | (n = 29) |
| | Age (years; mean ± s.d.) | 46.7 ± 16.7 | 52.1 ± 15.1 | 45.5 ± 17.2 | 0.219 |
| | Gender | | | | | | Male (%) | 21 (48) | 8 (53) | 12 (41) | 0.532 | | Female (%) | 23 (52) | 7 (47) | 17 (59) | |
| | BMI | 23.0 (21.0 – 26.0) | 23.0 (19.8 – 27.0) | 23.0 (21.0 – 26.0) | 0.854 |
| | Aetiology | | | | | | NRH (%) | 16 (36) | 6 (40) | 10 (34) | - | | CHF (%) | 8 (18) | 0 (0) | 8 (28) | - | | Schistosomiasis (%) | 6 (14) | 4 (27) | 2 (7) | - | | Idiopathic (%) | 6 (14) | 2 (13) | 4 (14) | - | | PVT (%) | 5 (11) | 2 (13) | 3 (10) | - | | Other (%) | 3 (7) | 1 (7) | 2 (7) | - | | Time to OGD (days) | 83.5 (30 – 121) | 63 (36 - 121) | 94 (29 - 124) | 0.815 |
| | Liver disease Severity | | | | | | MELD | 9.0 (8.0 – 12.0) | 9.0 (8.0 – 11.0) | 9.0 (8.0 – 12.0) | 0.661 | | Childs Pugh A (%) | 38 (86) | 13 (87) | 25 (86) | 0.966 | | Childs Pugh B (%) | 6 (14) | 2 (13) | 4 (14) | |
| | Fibrosis | | | | | | Laennec score at liver biopsy (mean ± s.d.) | 1.19 ± 1.05 | 1.18 ± 1.08 | 1.16 ± 1.07 | 0.953 | | FIB4 | 3.21 (1.66 – 5.01) | 3.17 (1.66 – 5.41) | 3.07 (1.55 – 4.68) | 0.541 | | APRI | 0.97 (0.53 – 1.55) | 0.89 (0.54 – 1.78) | 0.97 (0.51 – 1.53) | 0.789 | | LSM (kPa) | 8.7 (6.7 – 11.5) | 8.9 (4.8 – 10.3) | 8.6 (7.1 – 11.9) | 0.438 |
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