Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Table 3

Metaregression analysis in the binary classification of variable data using the odds ratio (OR).

LogOR	Exp(b)	Std. error	t		(95% conf. interval)
Regulation mode	0.0059773	0.6970161	0.01	0.993	−1.51269	1.524645
Country	−0.9125667	0.6038116	−1.51	0.157	−2.228159	0.4030257
miRNA profiling	1.916451	0.8301294	2.31	0.040	0.1077546	3.725148
Sample size	−0.55473	.5707856	−0.97	0.350	−1.798365	0.6889049

We used LogOR as response variables and used the regulation mode, miRNA profiling, country, and sample size as covariates. Estimate of between-study variance tau² = 0.4247. Residual variation due to heterogeneity: I-squared_res = 64.66%. Proportion of between-study variance explained: Adj. R-squared = 48.15%. Joint test for all covariates with Knapp–Hartung modification: Prob > F = 0.0964.