Canadian Journal of Gastroenterology and Hepatology

Research Article

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries

Table 2

Univariate and multivariate analyses of relationship between various clinical factors and overall survival (OS).


Variable	Category	Obs	Univariate analysis; OS			Multivariate analysis; OS
Variable	Category	Obs	HR	P	95%CI	HR	P	95%CI

Gender	M/F	48/38	0.747	0.194	0.481-1.160
Age	<64/≥64	40/46	1.709	0.017	1.102-2.652	1.478	0.097	0.932-2.344
PLT, 10⁹/L	<258.67/≥258.67	64/22	0.652	0.090	0.397-1.069
PDW, fL	<17.99/>=17.99	64/22	0.916	0.726	0.560-1.497
MPV, fL	<12.46/>=12.46	64/22	1.24	0.388	0.761- 2.021
LYM, 10⁹/L	<1.5/>=1.5	64/22	0.636	0.075	0.387-1.046
NEU, 10⁹/L	<7.12/>=7.12	64/22	1.160	0.553	0.711-1.891
PLR	<240.18/>=240.18	66/20	0.940	0.814	0.560-1.577
NLR	<6.17/>=6.17	65/21	1.820	0.020	1.098-3.018	1.457	0.178	0.843-2.517
APTT, s	<30.8/≥30.8	64/22	0.868	0.577	0.529-1.426
PT, s	<12.3/≥12.3	64/22	1.670	0.041	1.020-2.733	1.829	0.036	1.042-3.212
INR	<1.07/≥1.07	64/22	1.670	0.041	1.020-2.733
FIB, g/l	<4.49/≥4.49	64/22	1.393	0.196	0.843-2.304
TT, s	<18.75/≥18.75	65/21	0.853	0.528	0.519-1.399
DD, ug/ml	<1.11/≥1.11	63/21	1.263	0.341	0.781-2.043
ALB, g/L	<35/≥35	38/48	0.618	0.032	0.397-0.960	1.238	0.459	0.704-2.176
CRP, mg/L	<10/≥10	25/61	1.304	0.272	0.812-2.092
GPS	0/1-2	19/67	1.198	0.494	0.714-2.011
CA199, U/ml	<37/>=37	28/58	1.295	0.269	0.818-2.050
CA125, U/ml	<36.49/≥36.49	59/27	0.970	0.896	0.611-1.537
CEA, ng/ml	<5.1/≥5.1	57/29	1.24	0.350	0.79-1.96
Differentiation	Middle-High/Low	57/29	3.382	0.001	2.033-5.628	3.046	0.001	1.667-5.566
Lymph	(+)/(-)	39/47	0.712	0.127	0.459-1.102
Nerve	(+)/(-)	60/26	0.756	0.240	0.475-1.205
Stage	I-II/III-IVA	62/24	1.840	0.015	1.126-3.008	1.621	0.062	0.975-2.695

Obs, observation, PLT, platelet count, PDW, platelet distribution width, MPV, mean platelet volume, LYM, lymphocyte count NEU, neutrophil count, PLR, platelet-lymphocyte ratio, NLR, neutrophil-lymphocyte ratio, ALB, albumin, CRP, C-reactive protein, GPS, Glasgow Prognostic Score, APTT, activated partial thromboplastin time, PT, prothrombin time, INR, international normalized ratio, FIB, fibrinogen, TT, thrombin time, DD: D-dimer, Lymph: lymph node metastasis, and Nerve, nerve invasion. OS, overall survival and RFS, recurrence-free survival.