Canadian Journal of Gastroenterology and Hepatology

Research Article

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries

Table 3

Univariate and multivariate analyses of relationship between various clinical factors and recurrence-free survival (RFS).


Variable	Category	Obs	Univariate analysis; RFS			Multivariate analysis; RFS
Variable	Category	Obs	HR	P	95%CI	HR	P	95%CI

Gender	M/F	48/38	0.786	0.278	0.508-1.215
Age	<64/≥64	40/46	1.650	0.023	1.071-2.542	1.336	0.215	0.845-2.113
PLT, 10⁹/L	<258.67/≥258.67	64/22	0.677	0.124	0.413-1.112
PDW, fL	<17.99/>=17.99	64/22	0.996	0.986	0.609-1.627
MPV, fL	<12.46/>=12.46	64/22	1.101	0.700	0.675-1.794
LYM, 10⁹/L	<1.5/>=1.5	64/22	0.691	0.143	0.422-1.133
NEU, 10⁹/L	<7.12/>=7.12	64/22	1.147	0.582	0.704-1.868
PLR	<240.18/>=240.18	66/20	0.981	0.941	0.586-1.642
NLR	<6.17/>=6.17	65/21	1.590	0.069	0.965-2.622
APTT, s	<30.8/≥30.8	64/22	0.950	0.838	0.578-1.559
PT, s	<12.3/≥12.3	64/22	1.827	0.019	1.105-3.018	1.826	0.033	1.049-3.177
INR	<1.07/≥1.07	64/22	1.827	0.019	1.105-3.018
FIB, g/l	<4.49/≥4.49	64/22	1.240	0.397	0.753-2.04
TT, s	<18.75/≥18.75	65/21	0.800	0.379	0.487-1.315
DD, ug/mL	<1.11/≥1.11	63/21	1.410	0.162	0.871-2.285
ALB, g/L	<35/≥35	38/48	0.561	0.011	0.359-0.877	0.939	0.820	0.547-1.612
CRP, mg/L	<10/≥10	25/61	1.284	0.301	0.799-2.064
GPS	0/1-2	19/67	1.289	0.338	0.767-2.167
CA199, U/ml	<37/>=37	28/58	1.195	0.447	0.755-1.889
CA125, U/ml	<36.49/≥36.49	59/27	0.932	0.765	0.589-1.476
CEA, ng/ml	<5.1/≥5.1	57/29	1.120	0.626	0.711-1.763
Differentiation	Middle-High/Low	57/29	3.384	0.001	2.021-5.667	3.090	0.001	1.748-5.461
Lymph	(+)/(-)	39/47	0.690	0.094	0.447-1.064
Nerve	(+)/(-)	60/26	0.692	0.124	0.433-1.107
Stage	I-II/III-IVA	62/24	2.154	0.003	1.295-3.583	2.040	0.008	1.201-3.467

Obs, observation, PLT, platelet count, PDW, platelet distribution width, MPV, mean platelet volume, LYM, lymphocyte count, NEU, neutrophil count, PLR, platelet-lymphocyte ratio, NLR, neutrophil-lymphocyte ratio, ALB, albumin, CRP, C-reactive protein, GPS, Glasgow Prognostic Score, APTT, activated partial thromboplastin time, PT, prothrombin time, INR, international normalized ratio, FIB, fibrinogen, TT, thrombin time, DD: D-dimer, Lymph: lymph node metastasis, and Nerve, nerve invasion. OS, overall survival and RFS, recurrence-free survival.