The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Table 3
Hazard ratios of incident NAFLD.
Men
Model 1
Model 2
Model 3
Age, years
1.00 (1.00–1.01)
0.319
1.01 (1.00–1.01)
0.047
1.01 (1.00–1.01)
0.007
TyG-index tertiles:
Highest (8.48 ≤ TyG)
2.69 (2.35–3.08)
<0.001
2.01 (1.75–2.31)
<0.001
1.93 (1.68–2.22)
<0.001
Middle (8.00 ≤ TyG < 8.48)
1.64 (1.42–1.89)
<0.001
1.44 (1.25–1.67)
<0.001
1.42 (1.23–1.64)
<0.001
Lowest (TyG < 8.00)
Ref
–
Ref
–
Ref
—
BMI (kg/m2)
–
–
1.22 (1.20–1.24)
<0.001
1.21 (1.18–1.23)
<0.001
Log (alcohol consumption + 1)
–
–
0.91 (0.89–0.93)
<0.001
0.91 (0.89–0.93)
<0.001
Exercise, yes
–
–
0.77 (0.67–0.88)
<0.001
0.78 (0.68–0.89)
<0.001
Past-smoker
–
–
0.98 (0.86–1.11)
0.757
0.98 (0.86–1.11)
0.734
Current-smoker
–
–
0.92 (0.82–1.03)
0.142
0.92 (0.82–1.03)
0.139
Alanine transaminase (IU/L)
–
–
–
–
1.01 (1.01–1.01)
<0.001
Women
Model 1
Model 2
Model 3
Age, years
1.03 (1.02–1.04)
<0.001
1.03 (1.02–1.04)
<0.001
1.03 (1.02–1.04)
<0.001
TyG-index tertiles:
Highest (7.97 ≤ TyG)
3.94 (3.08–5.12)
<0.001
2.47 (1.92–3.22)
<0.001
2.46 (1.91–3.21)
<0.001
Middle (7.53 ≤ TyG < 7.97)
1.95 (1.49–2.57)
<0.001
1.59 (1.22–2.10)
<0.001
1.59 (1.22–2.10)
<0.001
Lowest (TyG < 7.53)
Ref
–
Ref
–
Ref
–
BMI (kg/m2)
–
–
1.32 (1.29–1.35)
<0.001
1.32 (1.29–1.35)
<0.001
Log (alcohol consumption + 1)
–
–
0.94 (0.89–0.99)
0.013
0.94 (0.89–0.99)
0.013
Exercise, yes
–
–
0.92 (0.73–1.13)
0.426
0.92 (0.73–1.13)
0.436
Past-smoker
–
–
0.93 (0.62–1.32)
0.686
0.93 (0.62–1.32)
0.685
Current-smoker
–
–
1.13 (0.83–1.51)
0.405
1.14 (0.83–1.51)
0.406
Alanine transaminase (IU/L)
–
–
–
–
1.00 (1.00–1.01)
0.099
The analysis of past and current smokers used nonsmoker as the reference. The analysis of the TyG-index used the lowest TyG-index tertile as the reference.
